Clinical relevance Calcineurin

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1 clinical relevance

1.1 rheumatic diseases
1.2 schizophrenia
1.3 diabetes





clinical relevance
rheumatic diseases

calcineurin inhibitors prescribed adult rheumatoid arthritis (ra) single drug or in combination methotrexate. microemulsion formulation approved u.s. food , drug administration treatment of severely active ra. prescribed for: psoriatic arthritis, psoriasis, acute ocular behçet’s disease, juvenile idiopathic arthritis, adult , juvenile polymyositis , dermatomyositis, adult , juvenile systemic lupus erythematosus, adult lupus membranous nephritis, systemic sclerosis, aplastic anemia, steroid-resistant nephrotic syndrome, atopic dermatitis, severe corticosteroid-dependent asthma, severe ulcerative colitis, pemphigus vulgaris, myasthenia gravis, , dry eye disease, or without sjögren s syndrome (administered ophthalmic emulsion).


schizophrenia

calcineurin linked receptors several brain chemicals including glutamate, dopamine , gaba. experiment genetically-altered mice not produce calcineurin showed similar symptoms in humans schizophrenia: impairment in working memory, attention deficits, aberrant social behavior, , several other abnormalities characteristic of schizophrenia.


diabetes

calcineurin along nfat, may improve function of diabetics pancreatic beta cells. tacrolimus contributes frequent development of new diabetes following renal transplantation.


calcineurin/nfat signaling required perinatal lung maturation , function.








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