Synthesis Ciclacillin

cyclacillin synthesis:

reaction of cyclohexanone ammonium carbonate , kcn under conditions of bucherer-bergs reaction led hydantoin 1. on acid hydrolysis, α-amino acid 2 resulted. treatment phosgene both protected amino group , activated carboxyl group toward amide formation (as 3) , reaction 6-aminopenicillanic acid (6-apa) gave cyclacillin (4).

interestingly, artifice seems have worked, since cyclacillin more active in vivo in vitro spectrum suggests likely.